Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21487341 | 0.80 | GPR35 (0.46) | ALDH1A1CYP1A2MAPTMAPK1TDP1 | |
| SCHEMBL29617721 | 0.74 | TDP1 (0.44) | ALDH1A1CYP3A4CYP1A2MAPTPKM | |
| SCHEMBL2132590 | 0.74 | TDP1 (0.44) | ALDH1A1CYP3A4CYP1A2MAPTPKM | |
| SCHEMBL26598264 | 0.74 | ERN1 (0.44) | ALDH1A1CYP3A4CYP1A2MAPTPKM | |
| SCHEMBL432390 | 0.73 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CYP1A2MAPTESPL1 | |
| SCHEMBL9677433 | 0.73 | CYP1A2 (0.48) | ALDH1A1CYP3A4CYP1A2MAPTPKM | |
| SCHEMBL9222965 | 0.72 | ALDH1A1 (0.55) | ALDH1A1CYP1A2MAPTESPL1ATM | |
| SCHEMBL25424202 | 0.72 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP1A2MAPTPKM | |
| SCHEMBL429810 | 0.72 | ALDH1A1 (0.47) | ALDH1A1CYP3A4MAPTPKMMAPK1 | |
| SCHEMBL32669242 | 0.72 | ALDH1A1 (0.39) | ALDH1A1CYP3A4CYP1A2MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |