Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573295 | 0.85 | MAPT (0.42) | DDB1CRBNMAPTALDH1A1NPC1 | |
| SCHEMBL2348483 | 0.81 | ALDH1A1 (0.40) | DDB1CRBNMAPTALDH1A1NPC1 | |
| SCHEMBL21285241 | 0.80 | GPR119 (0.42) | DDB1CRBNMAPTALDH1A1NPC1 | |
| SCHEMBL4481859 | 0.78 | TACR1 (0.48) | USP30MAPTALDH1A1NPC1MAPK1 | |
| SCHEMBL104498 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 | |
| SCHEMBL12908934 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 | |
| SCHEMBL21241481 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 | |
| SCHEMBL31561924 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 | |
| SCHEMBL31372297 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 | |
| SCHEMBL28441771 | 0.77 | USP2 (0.44) | DDB1CRBNMAPTALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555070-B1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2023-08-09 | — | — | EP | disclosed |