Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.49 |
| ▸ | CTRC | Q99895 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25959245 | 0.89 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL23742640 | 0.89 | ABL1 (0.61) | ABL1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23742655 | 0.86 | ABL1 (0.59) | ABL1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL25959089 | 0.83 | CCR4 (0.54) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL25959167 | 0.82 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL23742653 | 0.82 | ALOX5 (0.71) | NPC1RAB9AMEN1KMT2AALOX5 | |
| SCHEMBL23742674 | 0.82 | MEN1 (0.57) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL23742661 | 0.81 | MAPT (0.58) | ABL1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23742652 | 0.79 | NPY5R (0.69) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL23742583 | 0.79 | CCR4 (0.67) | NPC1RAB9AMEN1KMT2ASENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SOUTHERN RES INST (US) | 2023-09-14 | — | — | US | disclosed |
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SOUTHERN RESEARCH INSTITUTE (US) | 2023-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718593-B2 | 2,5-aryl-thiazole analogs for the treatment of neurodegenerative diseases | SMN1; SMN2, TDP2, TDP1 | ABL1 2444/4885NPC1 1820/4885RAB9A 2604/4885 |
| US-20230286933-A1 | 2,5-ARYL-THIAZOLE ANALOGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, TDP2, TDP1 | ABL1 2444/4885NPC1 1820/4885RAB9A 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.