Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.73 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | PYGL | P06737 | 1/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4094329 | 0.85 | KMT2A (0.66) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL2624442 | 0.82 | SMN1; SMN2 (0.81) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A | |
| SCHEMBL259603 | 0.81 | ALDH1A1 (0.62) | SMN1; SMN2POLBRAB9ANPC1KMT2A | |
| SCHEMBL5834186 | 0.81 | KMT2A (0.63) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A | |
| SCHEMBL219394 | 0.80 | SMN1; SMN2 (0.81) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A | |
| SCHEMBL7122268 | 0.78 | KMT2A (0.56) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL6779077 | 0.76 | KMT2A (0.70) | SMN1; SMN2RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL5834652 | 0.76 | KMT2A (0.70) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A | |
| SCHEMBL7743046 | 0.76 | KMT2A (0.81) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A | |
| SCHEMBL7079557 | 0.75 | CYP11B1 (0.74) | SMN1; SMN2POLBCACNA1BAPBA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067586-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
| US-20070037805-A1 | Fused heteroaryl derivatives | HAYAKAWA MASAHIKO | 2007-02-15 | — | — | US | disclosed |
| US-20070037805-A1 | Fused heteroaryl derivatives | HAYAKAWA MASAHIKO | 2007-02-15 | — | — | US | disclosed |
| US-7173029-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
| US-7173029-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | SMN1; SMN2 4764/4885POLB 2203/4885CACNA1B 3179/4885 |
| US-20070037805-A1 | Fused heteroaryl derivatives | PIK3CD, PIK3R3, PIK3C2A | SMN1; SMN2 4764/4885POLB 2203/4885CACNA1B 3179/4885 |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | SMN1; SMN2 4764/4885POLB 2203/4885CACNA1B 3179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.