Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090211 | 0.74 | MTNR1B (0.62) | MTNR1AMTNR1BMAPT | |
| SCHEMBL12963096 | 0.74 | SYK (0.49) | MTNR1AMTNR1BF2THRBNR1H4 | |
| SCHEMBL30515092 | 0.73 | CYP3A4 (0.56) | HIF1ATOP1CYP3A4MAPT | |
| SCHEMBL25336536 | 0.73 | CYP3A4 (0.56) | HIF1ATOP1CYP3A4MAPT | |
| SCHEMBL30515013 | 0.73 | CYP3A4 (0.56) | HIF1ATOP1CYP3A4MAPT | |
| SCHEMBL25320764 | 0.73 | CYP3A4 (0.56) | HIF1ATOP1CYP3A4MAPT | |
| SCHEMBL29346756 | 0.73 | ALDH1A1 (0.49) | HIF1AMAPT | |
| SCHEMBL25320768 | 0.73 | CYP3A4 (0.56) | HIF1ATOP1CYP3A4MAPT | |
| SCHEMBL25959894 | 0.72 | TOP1 (0.43) | HIF1AMTNR1AMTNR1BTOP1SIRT2 | |
| SCHEMBL7801099 | 0.71 | MAPK1 (0.58) | MTNR1AMTNR1BMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146989-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |