SCHEMBL2596071

SCHEMBL2596071

C[C@H]1CCC[N+]1(c1ccc2c(c1)CCN(C(=O)Nc1ccc(-c3ccccc3)cc1)C2)[C@H]1CCNC1

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 2/20 0.42
RAB9A P51151 11/20 0.42
NPC1 O15118 10/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
TP53 P04637 1/20 0.42
ALDH1A1 P00352 1/20 0.41
TAS1R3 Q7RTX0 1/20 0.41
TAS1R1 Q7RTX1 1/20 0.41
TAS1R2 Q8TE23 1/20 0.41
THRB P10828 1/20 0.41
NAMPT P43490 5/20 0.40
MAPK1 P28482 1/20 0.40
KMT2A Q03164 2/20 0.40
ATM Q13315 1/20 0.40
MAPT P10636 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
MEN1 O00255 1/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14776067 0.85 F10 (0.36)
SCHEMBL2590075 0.82 DPP8 (0.37) ALDH1A1
SCHEMBL2595667 0.80 F10 (0.43) SMN1; SMN2ATM
SCHEMBL2596374 0.79 MCHR1 (0.35) RAB9ANPC1SMN1; SMN2TAS1R3TAS1R1
SCHEMBL2590071 0.77 HPGD (0.48) SMN1; SMN2ALDH1A1NAMPT
SCHEMBL2595527 0.75 KEAP1 (0.38) ALDH1A1NAMPTKMT2AMAPTMEN1
SCHEMBL2593506 0.74 HRH3 (0.38)
SCHEMBL2596067 0.73 GRIN2D (0.44) MAPK1KMT2AMEN1
SCHEMBL2595524 0.72 F10 (0.37) SMN1; SMN2ALDH1A1KMT2AMEN1GAA
SCHEMBL2596377 0.72 HRH3 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569303-A1 SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2013-03-20 EP claimed
WO-2011143145-A1 SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-11-17 WO claimed
EP-2569303-A1 SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2013-03-20 EP disclosed
WO-2011143145-A1 SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-11-17 WO disclosed