Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 14/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 12/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 12/20 | 0.43 |
| ▸ | PLG | P00747 | 11/20 | 0.43 |
| ▸ | F2 | P00734 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595524 | 0.90 | F10 (0.37) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL14776067 | 0.88 | F10 (0.36) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL2596374 | 0.85 | MCHR1 (0.35) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL2590075 | 0.82 | DPP8 (0.37) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL2590071 | 0.80 | HPGD (0.48) | LMNASMN1; SMN2SYK | |
| SCHEMBL2596071 | 0.80 | ROCK2 (0.42) | ATMSMN1; SMN2 | |
| SCHEMBL2595527 | 0.79 | KEAP1 (0.38) | F10PRSS1PRSS2PRSS3PLG | |
| SCHEMBL2593506 | 0.79 | HRH3 (0.38) | — | |
| SCHEMBL2593504 | 0.78 | ESR2 (0.38) | ESR2 | |
| SCHEMBL2590061 | 0.78 | HRH3 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569303-A1 | SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | claimed |
| WO-2011143145-A1 | SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | claimed |
| EP-2569303-A1 | SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143145-A1 | SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | disclosed |