SCHEMBL2596285

SCHEMBL2596285

Nc1cccc(C(c2ccccc2)(C(F)(F)F)C(F)(F)F)c1N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
TSHR P16473 2/20 0.37
KCNN4 O15554 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
MAPT P10636 3/20 0.36
GAA P10253 2/20 0.36
RAB9A P51151 1/20 0.36
MAPK1 P28482 2/20 0.34
CD44 P16070 1/20 0.33
PDK2 Q15119 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA5A P35218 1/20 0.33
CA9 Q16790 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16610456 0.86 ALDH1A1 (0.41) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL8655007 0.86 CD44 (0.39) ALDH1A1TSHRSMN1; SMN2MAPTGAA
SCHEMBL27562842 0.81 ALDH1A1 (0.39) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL29572291 0.81 ALDH1A1 (0.39) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL6319187 0.80 ALDH1A1 (0.35) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL19070530 0.77 CD44 (0.39) ALDH1A1TSHRSMN1; SMN2MAPTCD44
SCHEMBL3132847 0.76 KCNN4 (0.42) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL10784751 0.76 CD44 (0.38) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT
SCHEMBL8505978 0.76 MAPT (0.43) ALDH1A1TSHRKCNN4MAPTGAA
SCHEMBL222895 0.75 KCNN4 (0.53) ALDH1A1TSHRKCNN4SMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569081-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME Air Products and Chemicals, Inc. (US) 2013-03-20 EP disclosed
WO-2011143530-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2011-11-17 WO disclosed