Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.35 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.35 |
| ▸ | RPS17 | P08708 | 1/20 | 0.35 |
| ▸ | RPSA | P08865 | 1/20 | 0.35 |
| ▸ | RPS2 | P15880 | 1/20 | 0.35 |
| ▸ | RPL35A | P18077 | 1/20 | 0.35 |
| ▸ | RPL7 | P18124 | 1/20 | 0.35 |
| ▸ | RPL17 | P18621 | 1/20 | 0.35 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.35 |
| ▸ | RPS3 | P23396 | 1/20 | 0.35 |
| ▸ | RPS12 | P25398 | 1/20 | 0.35 |
| ▸ | RPL13 | P26373 | 1/20 | 0.35 |
| ▸ | RPL10 | P27635 | 1/20 | 0.35 |
| ▸ | RPL12 | P30050 | 1/20 | 0.35 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 1/20 | 0.35 |
| ▸ | RPL22 | P35268 | 1/20 | 0.35 |
| ▸ | RPL4 | P36578 | 1/20 | 0.35 |
| ▸ | RPS19 | P39019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303713 | 0.79 | PDE10A (0.39) | PDE10AHTR2BTRPV1 | |
| SCHEMBL9984684 | 0.79 | PDE10A (0.39) | PDE10AHTR2BTRPV1 | |
| SCHEMBL2593828 | 0.79 | GPR119 (0.52) | — | |
| SCHEMBL9988088 | 0.75 | PDE10A (0.63) | PDE10A | |
| SCHEMBL9988573 | 0.73 | PDE10A (0.43) | PDE10ABACE1TRPV1 | |
| SCHEMBL9988016 | 0.73 | PDE10A (0.47) | PDE10ATRPV1 | |
| SCHEMBL3347819 | 0.71 | RAB9A (0.39) | PDE10AHTR2BTRPV1 | |
| SCHEMBL9988190 | 0.71 | PDE10A (0.60) | PDE10A | |
| SCHEMBL1577713 | 0.71 | PDE10A (0.44) | PDE10ATRPV1 | |
| SCHEMBL9988179 | 0.71 | PDE10A (0.64) | PDE10AHTR2BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140213572-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2014-07-31 | — | — | US | disclosed |
| EP-2569300-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | Amgen Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-20110306587-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. | 2011-12-15 | — | — | US | disclosed |
| WO-2011143365-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213572-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | PDE10A, PDE2A, PDE3A | PDE10A 1/4885BACE1 537/4885RPLP1 3465/4885 |
| US-20110306587-A1 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | PDE10A, PDE2A, PDE3A | PDE10A 1/4885BACE1 537/4885RPLP1 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.