SCHEMBL2596687

SCHEMBL2596687

CCc1cc(-c2nnc(S)n2-c2ccc3c(c2)[N]C(=O)N3)c(O)cc1O

nearest known ligand 0.34

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 7/20 0.34
HSP90AB1 P08238 3/20 0.34
GAA P10253 4/20 0.32
MAPT P10636 3/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
PAX8 Q06710 1/20 0.32
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
ALOX12 P18054 2/20 0.31
ALOX15 P16050 1/20 0.31
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
MET P08581 1/20 0.30
PIM1 P11309 1/20 0.30
LTK P29376 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL930067 0.81 CRBN (0.37) GAAKMT2A
SCHEMBL13983495 0.79 HSP90AA1 (0.33) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL930153 0.78 HSP90AA1 (0.34) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL12180142 0.78 HSP90AA1 (0.35) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL1148450 0.77 HSP90AA1 (0.32) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL3705085 0.77 GAA (0.35) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL1147910 0.77 HSP90AA1 (0.36) HSP90AA1HSP90AB1GAAMAPTKDM4E
SCHEMBL931110 0.77 PARP1 (0.45) LMNAKMT2AALDH1A1NPSR1
SCHEMBL13983480 0.76 APLNR (0.40) HSP90AA1GAAMAPTLMNAALDH1A1
SCHEMBL931175 0.76 HTR1A (0.34) HSP90AA1HSP90AB1GAAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011146801-A1 FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2011-11-24 WO claimed