SCHEMBL25967188

SCHEMBL25967188

Cc1cc(F)c(N2CCC(COc3cccc4ncc(=O)n(C)c34)CC2)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 12/20 0.41
DCPS Q96C86 2/20 0.38
SSTR2 P30874 1/20 0.37
EGFR P00533 1/20 0.37
FGFR1 P11362 1/20 0.37
FLT1 P17948 1/20 0.37
FLT4 P35916 1/20 0.37
KDR P35968 1/20 0.37
C5AR1 P21730 1/20 0.37
RBP4 P02753 1/20 0.36
TTR P02766 1/20 0.36
CYP2D6 P10635 1/20 0.36
KDM4C Q9H3R0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20613091 0.92 FFAR4 (0.41) FFAR4DCPSSSTR2EGFRFGFR1
SCHEMBL20612868 0.85 FFAR4 (0.41) FFAR4DCPSC5AR1RBP4TTR
SCHEMBL20612855 0.78 FFAR4 (0.43) FFAR4DCPSEGFRFGFR1FLT1
SCHEMBL20612865 0.75 FFAR4 (0.44) FFAR4C5AR1
SCHEMBL20613065 0.74 BRD4 (0.46) FFAR4C5AR1
SCHEMBL25966329 0.73 FFAR4 (0.41) FFAR4DCPSRBP4TTR
SCHEMBL20612999 0.72 FFAR4 (0.41) FFAR4DCPSSSTR2EGFRFGFR1
SCHEMBL25966351 0.72 HTR4 (0.48) FFAR4DCPSRBP4TTRCYP2D6
SCHEMBL20613002 0.72 FFAR4 (0.43) FFAR4
SCHEMBL20612924 0.72 PARP1 (0.46) FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421454-B9 PIPERIDINE DERIVATIVE OTSUKA PHARMA CO LTD (JP) 2023-08-09 EP disclosed