Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 1/20 | 0.41 |
| ▸ | SDC2 | P34741 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980629 | 1.00 | KMT2A (0.54) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL26346279 | 0.85 | MEN1 (0.50) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL16620050 | 0.85 | MEN1 (0.52) | KMT2AMEN1GAATDP1CA1 | |
| SCHEMBL9980688 | 0.85 | SDCBP (0.55) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL8140353 | 0.84 | KMT2A (0.49) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL31314679 | 0.84 | KMT2A (0.49) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL15663375 | 0.84 | MEN1 (0.43) | KMT2AMEN1GAATDP1CTSK | |
| SCHEMBL9980668 | 0.82 | CAPN1 (0.54) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL28230790 | 0.82 | MEN1 (0.51) | KMT2AMEN1GAATDP1CTSS | |
| SCHEMBL31069956 | 0.81 | KMT2A (0.46) | KMT2AMEN1GAATDP1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810129-B1 | PCSK9 ANTAGONIST BICYCLO-COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |