Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596854 | 0.67 | TGFBR1 (0.46) | TGFBR1CYP3A4CYP2C8ACVR1BACVRL1 | |
| SCHEMBL2596940 | 0.65 | TGFBR1 (0.67) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL320090 | 0.63 | TGFBR1 (0.49) | TGFBR1CYP3A4CYP2C8ACVR1BACVRL1 | |
| SCHEMBL2596766 | 0.62 | TGFBR1 (0.48) | TGFBR1CYP3A4CYP2C8 | |
| SCHEMBL21067138 | 0.62 | PDE1A (0.40) | — | |
| SCHEMBL21061239 | 0.62 | HTR1A (0.30) | — | |
| SCHEMBL2596782 | 0.61 | TGFBR1 (0.69) | TGFBR1CYP3A4 | |
| SCHEMBL21067120 | 0.60 | PDE1A (0.39) | CYP3A4 | |
| SCHEMBL5236107 | 0.60 | CYP1A2 (0.65) | — | |
| SCHEMBL2596786 | 0.60 | TGFBR1 (0.63) | TGFBR1CYP3A4CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | claimed |
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |