Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | LTK | P29376 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | PRKX | P51817 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
| ▸ | STK3 | Q13188 | 2/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.34 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25338181 | 1.00 | AAK1 (0.34) | AAK1ROCK2ROCK1PKN2RPS6KA5 | |
| SCHEMBL25969171 | 1.00 | AAK1 (0.34) | AAK1ROCK2ROCK1PKN2RPS6KA5 | |
| SCHEMBL25969167 | 0.92 | GFER (0.33) | AAK1IRAK4PIK3CDABL1EGFR | |
| SCHEMBL25339977 | 0.92 | GFER (0.33) | AAK1IRAK4PIK3CDABL1EGFR | |
| SCHEMBL23744953 | 0.87 | OPRM1 (0.39) | IRAK4RORC | |
| SCHEMBL25339817 | 0.86 | GFER (0.33) | IRAK4GFERRORC | |
| SCHEMBL25969170 | 0.86 | GFER (0.33) | IRAK4GFERRORC | |
| SCHEMBL21997531 | 0.85 | IRAK4 (0.39) | AAK1LRRK2IRAK4GFERRORC | |
| SCHEMBL21996690 | 0.85 | GFER (0.33) | IRAK4GFERRORC | |
| SCHEMBL23744955 | 0.85 | IRAK4 (0.39) | AAK1LRRK2IRAK4GFERRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147594-A2 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |