Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25969107 | 0.85 | KDM4E (0.69) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL26363706 | 0.85 | HTT (0.64) | TSHRMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30295828 | 0.82 | HDAC1 (0.59) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL29457946 | 0.82 | LMNA (0.64) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23297300 | 0.80 | HDAC1 (0.65) | TSHRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL17504167 | 0.79 | MEN1 (0.68) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23495266 | 0.79 | MAPT (0.64) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23297284 | 0.78 | MEN1 (0.60) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL18169206 | 0.78 | KDM4E (0.65) | TSHRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL23495412 | 0.78 | MAPT (0.59) | TSHRMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248972-A2 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3877052-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |