Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25969306 | 0.85 | TSHR (0.66) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL26363706 | 0.85 | HTT (0.64) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29457946 | 0.85 | LMNA (0.64) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL30297703 | 0.79 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL24029943 | 0.79 | MKNK1 (0.49) | KDM4EALDH1A1HSD17B10SMN1; SMN2POLB | |
| SCHEMBL18169216 | 0.78 | TP53 (0.65) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL23495112 | 0.78 | MEN1 (0.68) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL23495111 | 0.78 | MEN1 (0.68) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL11218973 | 0.77 | PDE4A (0.58) | KDM4EALDH1A1HSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL23495174 | 0.76 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877052-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |