SCHEMBL25969425

SCHEMBL25969425

COCCOC(=O)Nc1ccc(Cc2ccc(NC(=O)OCC(CO)(CO)COC(=O)Nc3ccc(Cc4ccc(NC(=O)OCCOC(C)C)cc4)cc3)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 8/20 0.39
NPC1 O15118 5/20 0.39
RAB9A P51151 5/20 0.39
HPGD P15428 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
SAE1 Q9UBE0 1/20 0.37
UBA2 Q9UBT2 1/20 0.37
HTT P42858 2/20 0.37
CASP1 P29466 1/20 0.36
CYP17A1 P05093 1/20 0.36
RECQL P46063 1/20 0.36
LMNA P02545 3/20 0.36
TP53 P04637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
ALDH1A1 P00352 1/20 0.35
MAPK1 P28482 1/20 0.35
TSHR P16473 2/20 0.35
MAPT P10636 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17547614 0.92 SAE1 (0.43) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL17549591 0.89 SAE1 (0.40) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL20932894 0.88 NPC1 (0.43) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL25917538 0.86 NPC1 (0.41) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL18869282 0.85 CYP17A1 (0.43) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL17552162 0.81 SMN1; SMN2 (0.40) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL9947412 0.80 SAE1 (0.44) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL17550776 0.78 SAE1 (0.41) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL25917537 0.78 SMN1; SMN2 (0.50) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1
SCHEMBL17550342 0.78 CYP17A1 (0.38) SMN1; SMN2NPC1RAB9AHPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240065373-A1 SOLE STRUCTURES INCLUDING POLYOLEFIN PLATES AND ARTICLES OF FOOTWEAR FORMED THEREFROM NIKE, INC. 2024-02-29 US disclosed
US-20230272563-A1 TEXTILES AND ARTICLES, AND PROCESSES FOR MAKING THE SAME NIKE, INC. 2023-08-31 US disclosed
US-11723429-B2 Articles including coated fibers and methods of making coated fibers and articles NIKE, INC. (US) 2023-08-15 US disclosed