Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25344068 | 0.89 | HSD17B10 (0.40) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24553224 | 0.89 | HSD17B10 (0.40) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL24192506 | 0.87 | PDK2 (0.35) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25969636 | 0.85 | L3MBTL1 (0.32) | L3MBTL1CA14HDAC1HDAC2HDAC6 | |
| SCHEMBL22276510 | 0.84 | PDK2 (0.40) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22276649 | 0.84 | PDK2 (0.40) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL224139 | 0.81 | PDK2 (0.38) | PDK2CHRNB2CHRNA4L3MBTL1CA14 | |
| SCHEMBL19266928 | 0.79 | PDK2 (0.38) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16205754 | 0.79 | PDK2 (0.38) | PDK2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL25937411 | 0.79 | PDK2 (0.38) | PDK2GPR88L3MBTL1CA14HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | BLOSSOMHILL THERAPEUTICS INC (US) | 2023-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257396-A1 | MACROCYCLES AND THEIR USE | VHL, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DLD | PDK2 580/4885CHRNB2 4783/4885CHRNB4 4849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.