Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597054 | 1.00 | GPR119 (0.35) | GPR119ROCK2CCNA2CDK2CDK5 | |
| SCHEMBL2597001 | 0.84 | FPR2 (0.41) | GPR119ROCK2CCNA2CDK2CDK5 | |
| SCHEMBL789215 | 0.84 | FPR2 (0.41) | GPR119ROCK2CCNA2CDK2CDK5 | |
| SCHEMBL15022867 | 0.81 | GPR119 (0.37) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2597193 | 0.81 | GPR119 (0.37) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL2598653 | 0.79 | BTK (0.38) | GPR119PLATSLC6A9 | |
| SCHEMBL796252 | 0.79 | BTK (0.38) | GPR119PLATSLC6A9 | |
| SCHEMBL2597108 | 0.78 | PTK6 (0.37) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL15022863 | 0.78 | PTK6 (0.37) | GPR119CCNA2CDK2CDK5CDK5R1 | |
| Hydrochloric Acid SCHEMBL797766 | 0.78 | BTK (0.37) | GPR119PLATSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |