Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23880068 | 0.91 | SCN9A (0.49) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL2733495 | 0.80 | SMN1; SMN2 (0.65) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL25972082 | 0.78 | HPGD (0.50) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL23880057 | 0.78 | SCN9A (0.47) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL25972074 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL23880060 | 0.75 | SCN9A (0.46) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL23880061 | 0.74 | SCN9A (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2ASCN9A | |
| SCHEMBL25972070 | 0.74 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL10203177 | 0.73 | L3MBTL3 (0.67) | ALDH1A1MEN1KMT2AL3MBTL1KCNH2 | |
| SCHEMBL23880056 | 0.73 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | BEIGENE, LTD. (KY) | 2023-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11725012-B2 | Imidazo[1,5-a]pyrazine derivatives as PI3K δ inhibitors | PIK3CD, PIK3R5, PIK3CA | ALDH1A1 1955/4885SMN1; SMN2 3205/4885HTT 3524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.