Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597279 | 1.00 | GPR119 (0.42) | GPR119SLC6A9KCNH2CXCR3SMN1; SMN2 | |
| SCHEMBL15022855 | 0.88 | SLC6A9 (0.46) | GPR119SLC6A9KCNH2CXCR3SMN1; SMN2 | |
| SCHEMBL15022856 | 0.88 | SLC6A9 (0.46) | GPR119SLC6A9KCNH2CXCR3SMN1; SMN2 | |
| SCHEMBL15023673 | 0.84 | SLC6A9 (0.45) | GPR119SLC6A9KCNH2CXCR3SMN1; SMN2 | |
| SCHEMBL2597325 | 0.83 | GPR119 (0.36) | GPR119SLC6A9KCNH2 | |
| SCHEMBL2597324 | 0.83 | GPR119 (0.36) | GPR119SLC6A9KCNH2 | |
| SCHEMBL12185832 | 0.81 | SLC6A9 (0.46) | GPR119SLC6A9KCNH2CXCR3PTGS1 | |
| SCHEMBL15022743 | 0.81 | SLC6A9 (0.46) | GPR119SLC6A9KCNH2CXCR3PTGS1 | |
| SCHEMBL15022662 | 0.78 | GPR119 (0.44) | GPR119SLC6A9KCNH2CYP2C9CYP3A4 | |
| SCHEMBL12185828 | 0.78 | GPR119 (0.44) | GPR119SLC6A9KCNH2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |