SCHEMBL25973237

SCHEMBL25973237

CCCCCCCCCCCCCCCCOCCCCOP(=O)(O)OC1[C@H]2O[C@@](C)(c3ccc4c(N)ncnn34)[C@H](O)[C@@]12O

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 1/20 0.35
▸ POLRMT O00411 1/20 0.34
▸ CYP3A4 P08684 7/20 0.33
▸ CYP2D6 P10635 7/20 0.33
▸ ADK P55263 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24305253 0.99 FGFR1 (0.36) FGFR1POLRMTCYP3A4CYP2D6ADK
SCHEMBL24305023 0.90 AKT1 (0.33) FGFR1POLRMTCYP3A4CYP2D6
SCHEMBL24304375 0.89 MAPK14 (0.34) FGFR1POLRMTCYP3A4CYP2D6
SCHEMBL26363887 0.88 AKT1 (0.32) FGFR1POLRMT
SCHEMBL25973609 0.88 AKT1 (0.32) FGFR1POLRMT
SCHEMBL25973375 0.87 POLRMT (0.32) POLRMT
SCHEMBL25973325 0.87 POLRMT (0.32) POLRMT
SCHEMBL25972996 0.87 AKT1 (0.31) POLRMT
SCHEMBL25958894 0.87 PIK3R1 (0.33) POLRMT
SCHEMBL25977396 0.87 AKT1 (0.31) POLRMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12030904-B2 Phospholipid compounds and uses thereof GILEAD SCIENCES, INC. (US) 2024-07-09 — — US disclosed
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF GILEAD SCIENCES, INC. 2023-08-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030904-B2 Phospholipid compounds and uses thereof PHOSPHO1, SGMS2, SGMS1 FGFR1 4843/4885POLRMT 371/4885CYP3A4 2243/4885
US-20230250117-A1 PHOSPHOLIPID COMPOUNDS AND USES THEREOF PHOSPHO1, SGMS2, SGMS1 FGFR1 4843/4885POLRMT 371/4885CYP3A4 2243/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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