Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12018135 | 0.95 | KMT2A (0.40) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| SCHEMBL39002 | 0.95 | KMT2A (0.40) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| Hydrochloric Acid SCHEMBL15203906 | 0.92 | KMT2A (0.39) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| SCHEMBL6247304 | 0.92 | KMT2A (0.39) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| SCHEMBL12018055 | 0.92 | ALDH1A1 (0.41) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| SCHEMBL16568777 | 0.90 | CYP2D6 (0.42) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| Hydrochloric Acid SCHEMBL6247228 | 0.90 | KMT2A (0.38) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| Hydrochloric Acid SCHEMBL11905280 | 0.89 | CHKA (0.41) | ALDH1A1KDM4E | |
| SCHEMBL29998442 | 0.89 | CYP2D6 (0.34) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 | |
| Water SCHEMBL30013627 | 0.87 | CYP2D6 (0.33) | KMT2ACYP2D6ALDH1A1KDM4ECHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675885-B1 | COMPOSITIONS AND METHODS OF BLEACHING | PROCTER & GAMBLE (US) | 2017-10-25 | — | — | EP | claimed |
| EP-2675880-B1 | LIQUID CLEANING COMPOSITIONS | PROCTER & GAMBLE (US) | 2016-12-14 | — | — | EP | claimed |
| US-20150232786-A1 | COMPOSITIONS AND METHODS OF BLEACHING | PROCTER & GAMBLE (US) | 2015-08-20 | — | — | US | claimed |
| US-8846596-B2 | Liquid cleaning compositions | THE PROCTER & GAMBLE COMPANY (US) | 2014-09-30 | — | — | US | claimed |
| EP-2675880-A1 | LIQUID CLEANING COMPOSITIONS | The Procter and Gamble Company (US) | 2013-12-25 | — | — | EP | claimed |
| EP-2675885-A1 | COMPOSITIONS AND METHODS OF BLEACHING | The Procter and Gamble Company (US) | 2013-12-25 | — | — | EP | claimed |
| US-20130143786-A1 | ACTIVATED PEROXIDE CLEANING COMPOSITIONS | ARKEMA INC. (US) | 2013-06-06 | — | — | US | claimed |
| EP-2571972-A1 | ACTIVATED PEROXIDE CLEANING COMPOSITIONS | ARKEMA INC. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2012145062-A1 | LIQUID CLEANING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2012-10-26 | — | — | WO | claimed |
| WO-2012112741-A1 | COMPOSITIONS AND METHODS OF BLEACHING | THE PROCTER & GAMBLE COMPANY (US) | 2012-08-23 | — | — | WO | claimed |
| US-20120205581-A1 | COMPOSITIONS AND METHODS OF BLEACHING | THE PROCTER & GAMBLE COMPANY | 2012-08-16 | — | — | US | claimed |
| US-20120208739-A1 | LIQUID CLEANING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY | 2012-08-16 | — | — | US | claimed |
| WO-2011146557-A1 | ACTIVATED PEROXIDE CLEANING COMPOSITIONS | ARKEMA INC. (US) | 2011-11-24 | — | — | WO | claimed |
| EP-1129164-B1 | BLEACH COMPOSITIONS | PROCTER & GAMBLE (US) | 2005-07-27 | — | — | EP | claimed |
| US-6667288-B2 | For use in laundry detergents | PROCTER & GAMBLE COMPANY | 2003-12-23 | — | — | US | claimed |
| US-20030040451-A1 | Bleach compositions | BURNS MICHAEL EUGENE (US) | 2003-02-27 | — | — | US | claimed |
| EP-2675885-B1 | COMPOSITIONS AND METHODS OF BLEACHING | PROCTER & GAMBLE (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2675880-B1 | LIQUID CLEANING COMPOSITIONS | PROCTER & GAMBLE (US) | 2016-12-14 | — | — | EP | disclosed |
| WO-2011146557-A1 | ACTIVATED PEROXIDE CLEANING COMPOSITIONS | ARKEMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| EP-1129164-B1 | BLEACH COMPOSITIONS | PROCTER & GAMBLE (US) | 2005-07-27 | — | — | EP | disclosed |