Sugi Predict

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SCHEMBL2597376

SCHEMBL2597376

CC(C)c1cc2[nH]c(=O)n(N(C(=O)CN3CCOCC3)S(C)(=O)=O)c(=O)c2cc1-c1ccnn1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IMPDH2 P12268 2/20 0.35
▸ CD274 Q9NZQ7 1/20 0.34
▸ HTR2A P28223 8/20 0.33
▸ HTR2C P28335 5/20 0.33
▸ HSD17B10 Q99714 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ EED O75530 1/20 0.32
▸ RBBP4 Q09028 1/20 0.32
▸ SUZ12 Q15022 1/20 0.32
▸ EZH2 Q15910 1/20 0.32
▸ AEBP2 Q6ZN18 1/20 0.32
▸ MAPK1 P28482 2/20 0.32
▸ CHUK O15111 1/20 0.32
▸ MAPK8 P45983 1/20 0.32
▸ CAMKK2 Q96RR4 1/20 0.32
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2597358 0.93 IMPDH2 (0.36) IMPDH2CD274HTR2AHTR2CHSD17B10
SCHEMBL2597215 0.92 ALDH1A1 (0.37) IMPDH2CD274HTR2AHTR2CHSD17B10
SCHEMBL2597448 0.87 HAVCR2 (0.31) IMPDH2HSD17B10KDM4EALDH1A1
SCHEMBL2597262 0.86 KDM4E (0.32) IMPDH2HSD17B10KDM4EALDH1A1HPGD
SCHEMBL2599399 0.86 HAVCR2 (0.31) IMPDH2
SCHEMBL2597409 0.84 HAVCR2 (0.32) IMPDH2HSP90AA1HSP90AB1
SCHEMBL2597335 0.84 KDM4E (0.35) HSD17B10KDM4EALDH1A1HPGDMEN1
SCHEMBL2597453 0.84 IMPDH2 (0.31) IMPDH2
SCHEMBL2597209 0.84 HAVCR2 (0.32) HSP90AA1HSP90AB1
SCHEMBL2597264 0.83 KDM4E (0.37) HSD17B10KDM4EALDH1A1HPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2571865-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES Novartis AG (CH) 2013-03-27 — — EP claimed
US-20130053381-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG 2013-02-28 — — US claimed
WO-2011144666-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG (CH) 2011-11-24 — — WO claimed
EP-2571865-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES Novartis AG (CH) 2013-03-27 — — EP disclosed
US-20130053381-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG 2013-02-28 — — US disclosed
US-20130053381-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG 2013-02-28 — — US disclosed
US-20130053381-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG 2013-02-28 — — US disclosed
WO-2011144666-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG (CH) 2011-11-24 — — WO disclosed
WO-2011144666-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES NOVARTIS AG (CH) 2011-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130053381-A1 2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL-SULFONAMIDE DERIVATIVES GRIK2, GRIK1, GRIK4 IMPDH2 1186/4885CD274 2713/4885HTR2A 705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.