Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25975282 | 0.96 | MAPK8 (0.55) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25975349 | 0.82 | MAPK8 (0.51) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25974122 | 0.81 | KDM4E (0.68) | MAPTKDM4ERAB9ATP53ALDH1A1 | |
| SCHEMBL25975317 | 0.81 | MAPK8 (0.53) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25974258 | 0.79 | MAPT (0.69) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25974110 | 0.79 | KDM4E (0.68) | MAPTKDM4ERAB9ATP53ALDH1A1 | |
| SCHEMBL25974099 | 0.78 | KDM4E (0.67) | MAPTKDM4ERAB9ATP53ALDH1A1 | |
| SCHEMBL25975420 | 0.77 | KDM4E (0.69) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25974797 | 0.76 | RAB9A (0.57) | MAPK8MAPK10BTKMRGPRX2MAPT | |
| SCHEMBL25974752 | 0.75 | MAPK8 (0.66) | MAPK8MAPK10BTKMRGPRX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141866-A1 | PYRAZOLOPYRIMIDINES AS MODULATORS OF SPERMINE OXIDASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | WO | disclosed |