Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | PDE9A | O76083 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6287500 | 0.78 | KDM4E (0.59) | GRM5GRM1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL25344584 | 0.73 | CYP17A1 (0.49) | GRM1SMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL30568732 | 0.73 | CYP17A1 (0.49) | GRM1SMN1; SMN2LMNAKDM4ERAB9A | |
| SCHEMBL20250861 | 0.71 | ALDH1A1 (0.42) | SMN1; SMN2LMNAKDM4ERAB9AALDH1A1 | |
| SCHEMBL2771903 | 0.71 | PDE9A (0.50) | PDE9APDE1C | |
| SCHEMBL16981667 | 0.71 | ALDH1A1 (0.47) | GRM5GRM1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL25343201 | 0.69 | SLC2A1 (0.45) | LMNAKDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL18343699 | 0.69 | PDE2A (0.49) | KDM4EALDH1A1POLBMAPTHPGD | |
| SCHEMBL2087096 | 0.67 | PDE9A (0.70) | SMN1; SMN2LMNARAB9AALDH1A1POLB | |
| SCHEMBL5009196 | 0.67 | ADORA1 (0.47) | SMN1; SMN2LMNAKDM4ERAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |