Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.54 |
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175236 | 0.85 | ALDH1A1 (0.49) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL5011669 | 0.83 | KDM4E (0.59) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL6281507 | 0.83 | KDM4E (0.58) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL26859548 | 0.81 | KDM4E (0.51) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL25975558 | 0.78 | GRM5 (0.44) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL20102975 | 0.76 | TYK2 (0.53) | HPGDMAPTSMN1; SMN2HTTGRM1 | |
| SCHEMBL4925190 | 0.76 | LMNA (0.69) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL6105611 | 0.76 | PIK3CA (0.47) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL30034914 | 0.75 | ALDH1A1 (0.67) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL2077026 | 0.75 | ALDH1A1 (0.67) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507780-B1 | PYRAZOLO-PYRIMIDINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-08-22 | — | — | EP | disclosed |
| US-6962915-B2 | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-11-08 | — | — | US | disclosed |
| US-20040023992-A1 | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023992-A1 | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors | MAP4K2, MAP3K19, BRAF | KDM4E 1430/4885HPGD 2023/4885HSD17B10 3467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.