Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | PTPRC | P08575 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL7486 | 0.86 | GAA (0.68) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| SCHEMBL22030672 | 0.86 | GAA (0.68) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL428479 | 0.86 | GAA (0.68) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL9135405 | 0.85 | GPR139 (0.56) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL1276160 | 0.84 | KDM4E (0.67) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL657588 | 0.84 | KDM4E (0.66) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL11709120 | 0.84 | MAPT (0.66) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL8165809 | 0.84 | MAPT (0.66) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL21569381 | 0.84 | MAPT (0.66) | GPR139KDM4EMAPTHIF1ASLC22A6 | |
| Hippuric Acid SCHEMBL15416338 | 0.84 | MAPT (0.66) | GPR139KDM4EMAPTHIF1ASLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146683-A1 | METHODS AND REAGENTS FOR METABOLOMICS AND HISTOLOGY IN A BIOLOGICAL SAMPLE AND A KIT FOR THE SAME | METABOLON, INC. (US) | 2011-11-24 | — | — | WO | disclosed |