Hippuric Acid

Hippuric Acid

SCHEMBL7486

O=C(O)CNC(=O)c1ccccc1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TPH1TPH2

The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.68
MAPT P10636 2/20 0.68
KDM4E B2RXH2 1/20 0.68
HIF1A Q16665 1/20 0.68
SLC22A6 Q4U2R8 1/20 0.68
SLC22A8 Q8TCC7 1/20 0.68
CA1 P00915 2/20 0.59
CA2 P00918 1/20 0.59
PTPRC P08575 2/20 0.57
CTSL P07711 1/20 0.57
PTPN13 Q12923 1/20 0.57
ATM Q13315 1/20 0.56
NPC1 O15118 3/20 0.55
RAB9A P51151 3/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
LMNA P02545 1/20 0.55
POLB P06746 1/20 0.55
GPR139 Q6DWJ6 1/20 0.54
HDAC3 O15379 1/20 0.54
CA12 O43570 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hippuric Acid SCHEMBL428479 1.00 GAA (0.68) GAAMAPTKDM4EHIF1ASLC22A6
SCHEMBL22030672 1.00 GAA (0.68) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL3448563 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL15416338 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL11656206 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL11709120 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL8165809 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL21569381 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL657588 0.98 KDM4E (0.66) GAAMAPTKDM4EHIF1ASLC22A6
Hippuric Acid SCHEMBL7398337 0.98 MAPT (0.66) GAAMAPTKDM4EHIF1ASLC22A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 41332 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
US-12638455-B2 Kidney health monitoring in hypertension patients THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-05-26 US claimed
WO-2026103747-A1 SALT OF THIAZOLE DERIVATIVE INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 江苏豪森药业集团有限公司 2026-05-21 WO claimed
EP-4745138-A1 THIO-GLUTARIMIDO ISOINDOLINONE DERIVATIVE, BIFUNCTIONAL PROTEIN DEGRADER CONTAINING SAME, AND USES THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP claimed
EP-4745135-A1 COMPOUND BASED ON THIO-GLUTARIMIDO ISOINDOLINONE SKELETON AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP claimed
EP-4745137-A1 GLUTARIMIDE ISOINDOLINONE SKELETON-BASED COMPOUND Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-05-20 EP claimed
CN-122070278-A Bifunctional protein degradation agent containing aryl substituted heteroaryl and application thereof 标新生物医药科技(上海)有限公司 2026-05-19 CN claimed
CN-122036704-A Free base crystal form or acid salt of biaryl compound, preparation method and medical application thereof 江苏豪森药业集团有限公司 2026-05-15 CN claimed
EP-3869192-B1 METHOD FOR QUANTITATIVE DETECTION OF VARIOUS METABOLITES IN BIOLOGICAL SAMPLE HUMAN METABOLOMICS INST INC (CN) 2026-05-13 EP claimed
US-12624050-B2 Three fused ring derivative-containing salt or crystal form and pharmaceutical composition thereof SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) 2026-05-12 US claimed
US-4414145-A Preparation and use of a 195M-AU-containing liquid BYK-MILLINKCRODT CIL B.V. (NL) 1983-11-08 US claimed
US-4292162-A A SOLUTION OF TRIS BUFFER, HIPPURIC ACID, AND A WATER-SOLUBLE HIPPURATE GELMAN SCIENCES, INC. (US) 1981-09-29 US claimed
US-4292154-A USING A UREA-, AN AMIDE-, OR AMINOCARBOAMIDE-CONTAINING CARBOXYLIC ACID AND THE CORRESPONDING ACID SALT GELMAN SCIENCES, INC. (US) 1981-09-29 US claimed
US-4284647-A ADMINISTERING BENZOIC OR PHENYLACETIC ACID THE JOHNS HOPKINS UNIVERSITY (US) 1981-08-18 US claimed
EP-0029284-A1 Method for the electrophoretic separation of proteins, a buffer solution and buffer compositions therefor GELMAN SCIENCES, INC. (US) 1981-05-27 EP claimed
US-4256731-A COMPRISING A CATIONIC MICROBIOCIDE AND A QUATERNARY AMMONIUM COMPOUND ALONG WITH INHIBITION DISCOLORATION-COMPOUNDS WHICH INCLUDE A NONIONIC SURFACTANT AND AN AMINO ACID OR A DI- OR TRICARBOXYLIC ACID BEECHAM, INC. (US) 1981-03-17 US claimed
US-4243749-A Immunoassay employing an enzyme label MILES YEDA LTD. (IL) 1981-01-06 US claimed
US-4148912-A ANTISECRETORY, ANTIULCER SCIENCE UNION ET CIE (FR) 1979-04-10 US claimed
US-4108726-A Sarcoidosis test RESEARCH CORPORATION (US) 1978-08-22 US claimed
US-3990955-A Electrodeposition of hard nickel THE INTERNATIONAL NICKEL COMPANY, INC. (US) 1976-11-09 US claimed