Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26477333 | 0.84 | NPC1 (0.47) | NPC1RAB9AMAPTNPSR1KMT2A | |
| SCHEMBL5204620 | 0.84 | LMNA (0.45) | KIF11LMNA | |
| SCHEMBL22275384 | 0.81 | NPC1 (0.45) | NPC1RAB9AMAPTNPSR1KMT2A | |
| SCHEMBL8989108 | 0.81 | MEN1 (0.44) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL22275580 | 0.80 | NPC1 (0.44) | NPC1RAB9AMAPTNPSR1KMT2A | |
| SCHEMBL14983674 | 0.78 | NPC1 (0.42) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL22283553 | 0.78 | NPC1 (0.60) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL3116025 | 0.77 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTNPSR1KMT2A | |
| SCHEMBL1773246 | 0.77 | NPC1 (0.50) | NPC1RAB9AMAPTNPSR1KMT2A | |
| SCHEMBL12173600 | 0.77 | NPC1 (0.53) | NPC1RAB9AMAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4289480-A2 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | F. Hoffmann-La Roche AG (CH) | 2023-12-13 | — | — | EP | disclosed |
| EP-3377474-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2023-08-16 | — | — | EP | disclosed |