Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804195 | 1.00 | CHRM2 (0.44) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1804194 | 1.00 | CHRM2 (0.44) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1804196 | 1.00 | CHRM2 (0.44) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1804594 | 0.79 | SIGMAR1 (0.48) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1804593 | 0.79 | SIGMAR1 (0.48) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1804592 | 0.79 | SIGMAR1 (0.48) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL1807582 | 0.73 | DRD2 (0.56) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL14303789 | 0.70 | SRD5A1 (0.38) | HTR2CADRA1ASLC6A3LMNAPOLB | |
| SCHEMBL6558486 | 0.69 | CHRM2 (0.44) | CHRM2HTR1AADRA2ADRD2GABRA1 | |
| SCHEMBL6558482 | 0.69 | CHRM2 (0.44) | CHRM2HTR1AADRA2ADRD2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |