Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860768 | 1.00 | DRD2 (0.44) | DRD2DRD3ALDH1A1ALDH3A1SMN1; SMN2 | |
| SCHEMBL860423 | 1.00 | DRD2 (0.44) | DRD2DRD3ALDH1A1ALDH3A1SMN1; SMN2 | |
| SCHEMBL860767 | 1.00 | DRD2 (0.44) | DRD2DRD3ALDH1A1ALDH3A1SMN1; SMN2 | |
| SCHEMBL2597997 | 1.00 | DRD2 (0.44) | DRD2DRD3ALDH1A1ALDH3A1SMN1; SMN2 | |
| SCHEMBL860422 | 1.00 | DRD2 (0.44) | DRD2DRD3ALDH1A1ALDH3A1SMN1; SMN2 | |
| SCHEMBL861657 | 0.88 | DRD2 (0.53) | DRD2DRD3SIGMAR1CCR5PDE9A | |
| SCHEMBL861658 | 0.88 | DRD2 (0.53) | DRD2DRD3SIGMAR1CCR5PDE9A | |
| SCHEMBL2598009 | 0.88 | DRD2 (0.53) | DRD2DRD3SIGMAR1CCR5PDE9A | |
| SCHEMBL2598010 | 0.88 | DRD2 (0.53) | DRD2DRD3SIGMAR1CCR5PDE9A | |
| SCHEMBL19818358 | 0.87 | DRD2 (0.50) | DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |