Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14744276 | 0.97 | CTSL (0.41) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL12775777 | 0.86 | CTSL (0.42) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL19575012 | 0.82 | P2RX7 (0.37) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL12775578 | 0.82 | CTSL (0.44) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL13428844 | 0.81 | P2RX7 (0.44) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL5521873 | 0.80 | P2RX7 (0.42) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL2055534 | 0.80 | P2RX7 (0.42) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL1134597 | 0.79 | P2RX7 (0.41) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL12975362 | 0.79 | P2RX7 (0.44) | P2RX7CTSLCA1CA2CA7 | |
| SCHEMBL941564 | 0.79 | P2RX7 (0.44) | P2RX7CTSLCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571881-A1 | PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144584-A1 | PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |