Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21876206 | 1.00 | NR1H4 (0.36) | NR1H4TRPC6POLQPDGFRBPDGFRA | |
| SCHEMBL21876207 | 1.00 | NR1H4 (0.36) | NR1H4TRPC6POLQPDGFRBPDGFRA | |
| SCHEMBL24458065 | 0.88 | NR1H4 (0.39) | NR1H4TRPC6POLQPDGFRBPDGFRA | |
| SCHEMBL22042496 | 0.75 | TRPC6 (0.32) | TRPC6PDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL31092646 | 0.75 | TRPC6 (0.32) | TRPC6PDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL26794450 | 0.75 | KDM1A (0.38) | TRPC6PDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL18663812 | 0.74 | PDE4A (0.41) | NR1H4 | |
| SCHEMBL25980360 | 0.74 | PDE4A (0.41) | NR1H4 | |
| SCHEMBL18640033 | 0.74 | PDE4A (0.41) | NR1H4 | |
| SCHEMBL21876170 | 0.72 | KDM4E (0.40) | NR1H4KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596053-B1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | ORGANOVO INC (US) | 2023-08-16 | — | — | EP | disclosed |