Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23554436 | 0.85 | ALDH1A1 (0.41) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL18937619 | 0.79 | ALDH1A1 (0.37) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL19629639 | 0.79 | KDM4E (0.37) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL26199736 | 0.79 | ALDH1A1 (0.37) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL4717573 | 0.74 | POLA1 (0.36) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL11077322 | 0.73 | ALDH1A1 (0.50) | POLA1ALDH1A1KDM4ECDK2ADORA3 | |
| SCHEMBL23420496 | 0.73 | KDM4E (0.34) | ALDH1A1KDM4EKDM5B | |
| SCHEMBL14930380 | 0.72 | ALDH1A1 (0.44) | POLA1ALDH1A1KDM4EMAPK14CDK2 | |
| SCHEMBL2008301 | 0.70 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPK14CDK2CDK1 | |
| SCHEMBL17776531 | 0.69 | GDA (0.46) | KDM4EROCK2ROCK1ADORA3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322803-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | BRISTOL MYERS SQUIBB CO (US) | 2023-10-12 | — | — | US | disclosed |
| EP-3870578-B1 | THERAPEUTIC COMPOUNDS | C4X DISCOVERY LTD (GB) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023073364-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS THAT ARE KEAP1 BINDERS | C4X DISCOVERY LIMITED (GB) | 2023-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322803-A1 | SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER | DDX21, HRAS, RPL17 | POLA1 689/4885ALDH1A1 1946/4885KDM4E 2305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.