Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15847931 | 0.72 | BACE1 (0.46) | HTR2CHTR2BHTR2AMEN1ALDH1A1 | |
| SCHEMBL4598182 | 0.71 | GRIN1 (0.36) | CHRM3CHRM2GRIN1GRIN2ANSD3 | |
| SCHEMBL4198633 | 0.66 | CHRM3 (0.70) | CHRM3CHRM2 | |
| SCHEMBL22269354 | 0.65 | OPRL1 (0.47) | HTR2CHTR2B | |
| SCHEMBL4598539 | 0.64 | NSD3 (0.34) | HTR2CHTR2BHTR2ACHRM3CHRM2 | |
| SCHEMBL13999790 | 0.64 | MAPK1 (0.39) | HTR2CHTR2BHTR2ACYP3A4TSHR | |
| SCHEMBL13451396 | 0.64 | HTR2C (0.43) | HTR2CHTR2BHTR2AMAPK1 | |
| SCHEMBL25966765 | 0.64 | TP53 (0.35) | HTR2CHTR2BHTR2AHSD11B1 | |
| SCHEMBL5179386 | 0.63 | GRIN1 (0.38) | HTR2CHTR2BHTR2ACHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL3259793 | 0.63 | HTR2C (0.42) | HTR2CHTR2BHTR2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571864-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146335-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |