Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.36 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179386 | 0.89 | GRIN1 (0.38) | GRIN1GRIN2ANSD3GRIN2BKDM4E | |
| SCHEMBL4598539 | 0.88 | NSD3 (0.34) | GRIN1GRIN2ANSD3GRIN2BKDM4E | |
| SCHEMBL4597278 | 0.82 | OPRL1 (0.33) | GRIN1GRIN2ANSD3GRIN2BKDM4E | |
| SCHEMBL4626507 | 0.73 | NSD3 (0.36) | NSD3KDM4ECHRM2CHRM3ALDH1A1 | |
| SCHEMBL4610698 | 0.73 | NSD3 (0.36) | NSD3KDM4ECHRM2CHRM3ALDH1A1 | |
| SCHEMBL4415834 | 0.72 | BACE1 (0.36) | GRIN1GRIN2ANSD3GRIN2BKDM4E | |
| SCHEMBL4595948 | 0.72 | BACE1 (0.36) | GRIN1GRIN2ANSD3GRIN2BKDM4E | |
| SCHEMBL2598433 | 0.71 | HTR2C (0.40) | GRIN1GRIN2ANSD3CHRM2CHRM3 | |
| SCHEMBL4597825 | 0.71 | CHRM2 (0.39) | GRIN2BHTR1ASLC6A4CHRM2CHRM3 | |
| SCHEMBL4596592 | 0.71 | MMP13 (0.36) | NSD3SLC6A4CHRM2CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |