⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18383123 | 0.79 | AKR1B1 (0.33) | — | |
| SCHEMBL5496629 | 0.79 | AKR1B1 (0.33) | — | |
| SCHEMBL19690615 | 0.76 | AKR1B1 (0.31) | — | |
| SCHEMBL8626838 | 0.74 | AKR1B1 (0.31) | — | |
| SCHEMBL4321542 | 0.73 | — | — | |
| SCHEMBL19690518 | 0.72 | — | — | |
| SCHEMBL1560450 | 0.72 | TRPA1 (0.41) | — | |
| SCHEMBL27803525 | 0.72 | TRPA1 (0.41) | — | |
| SCHEMBL28284078 | 0.70 | HTT (0.34) | — | |
| SCHEMBL198041 | 0.70 | AKR1B1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368643-A1 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF | UNIV MCGILL (CA) | 2015-12-24 | — | — | US | claimed |
| US-20130203977-A1 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2013-08-08 | — | — | US | claimed |
| US-20050142535-A1 | Ogligonucleotides comprising alternating segments and uses thereof | MCGILL UNIVERISTY (CA) | 2005-06-30 | — | — | US | claimed |
| CN-116676305-A | High specificity genome editing using chemically modified guide RNAs | 安捷伦科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-109563514-B | Highly specific genome editing using chemically modified guide RNAs | 安捷伦科技有限公司 | 2023-03-10 | — | — | CN | disclosed |
| US-9902953-B2 | Oligonucleotides comprising alternating segments and uses thereof | MCGILL UNIVERSITY (CA) | 2018-02-27 | — | — | US | disclosed |
| US-9493772-B2 | Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2016-11-15 | — | — | US | disclosed |
| US-20150368643-A1 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF | UNIV MCGILL (CA) | 2015-12-24 | — | — | US | disclosed |
| US-20140343124-A1 | METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IN RENAL CELL CARCINOMA IN MALIGNANT GLIOMAS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2014-11-20 | — | — | US | disclosed |
| US-8765708-B2 | Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2014-07-01 | — | — | US | disclosed |
| US-20130203977-A1 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF | MCGILL UNIVERSITY (CA) | 2013-08-08 | — | — | US | disclosed |
| US-20130197057-A1 | METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IN RENAL CELL CARCINOMA IN MALIGNANT GLIOMAS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2013-08-01 | — | — | US | disclosed |
| WO-2013075233-A1 | METHOD FOR TREATING BRAIN CANCER | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2013-05-30 | — | — | WO | disclosed |
| EP-2571989-A1 | METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED I RENAL CELL CARCINOMA I MALIGNANT GLIOMAS | The Royal Institution for the Advancement of Learning / McGill University (CA) | 2013-03-27 | — | — | EP | disclosed |
| US-8278103-B2 | sugar-modified nucleosides and 2'-deoxynucleosides; sugar-modified nucleotides and 2'-deoxynucleotides; RNase H mediated cleavage associated with a reverse transcriptase of a virus | MCGILL UNIVERSITY (CA) | 2012-10-02 | — | — | US | disclosed |
| WO-2011143762-A1 | METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IΝ RENAL CELL CARCINOMA IΝ MALIGNANT GLIOMAS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY (CA) | 2011-11-24 | — | — | WO | disclosed |
| EP-1470144-B1 | OLIGONUCLEOTIDES COMPRISING ALTERNATING SEGMENTS AND USES THEREOF | UNIV MCGILL (CA) | 2008-12-03 | — | — | EP | disclosed |
| US-20050142535-A1 | Ogligonucleotides comprising alternating segments and uses thereof | MCGILL UNIVERISTY (CA) | 2005-06-30 | — | — | US | disclosed |
| US-6495672-B1 | DIAGNOSIS AND SEPARATION THROUGH TRIPLEX BINDING | ISIS PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |