Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 13/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 6/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803415 | 1.00 | GPR119 (0.47) | GPR119BRD4USP30BRD2BRD3 | |
| SCHEMBL1803418 | 1.00 | GPR119 (0.47) | GPR119BRD4USP30BRD2BRD3 | |
| SCHEMBL1804301 | 0.88 | BRD4 (0.42) | BRD4BRD2BRD3 | |
| SCHEMBL1804297 | 0.88 | BRD4 (0.42) | BRD4BRD2BRD3 | |
| SCHEMBL1804300 | 0.88 | BRD4 (0.42) | BRD4BRD2BRD3 | |
| SCHEMBL1806634 | 0.85 | USP30 (0.42) | GPR119USP30PIM1PIM2BTK | |
| SCHEMBL1806636 | 0.85 | USP30 (0.42) | GPR119USP30PIM1PIM2BTK | |
| SCHEMBL1805475 | 0.81 | HDAC2 (0.51) | USP30BTK | |
| SCHEMBL1805473 | 0.81 | HDAC2 (0.51) | USP30BTK | |
| SCHEMBL1808022 | 0.80 | USP30 (0.41) | GPR119USP30PIM1PIM2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |