Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CCL2 | P13500 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 7/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861232 | 1.00 | BACE1 (0.41) | BACE1ACMSDBRD4CCL2KDM4E | |
| SCHEMBL2598851 | 1.00 | BACE1 (0.41) | BACE1ACMSDBRD4CCL2KDM4E | |
| SCHEMBL861233 | 1.00 | BACE1 (0.41) | BACE1ACMSDBRD4CCL2KDM4E | |
| SCHEMBL860481 | 0.85 | BACE1 (0.43) | BACE1ACMSDBRD4CCL2KDM4E | |
| SCHEMBL860482 | 0.85 | BACE1 (0.43) | BACE1ACMSDBRD4CCL2KDM4E | |
| SCHEMBL1805583 | 0.82 | ACMSD (0.39) | BACE1ACMSDSLC5A1HCRTR1HCRTR2 | |
| SCHEMBL2598841 | 0.82 | ACMSD (0.39) | BACE1ACMSDSLC5A1HCRTR1HCRTR2 | |
| SCHEMBL2598843 | 0.82 | ACMSD (0.39) | BACE1ACMSDSLC5A1HCRTR1HCRTR2 | |
| SCHEMBL1805585 | 0.82 | ACMSD (0.39) | BACE1ACMSDSLC5A1HCRTR1HCRTR2 | |
| SCHEMBL1804449 | 0.81 | CHEK1 (0.43) | LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |