Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861846 | 1.00 | MAOA (0.40) | MAOAMAOBPARP1NR1H3TAAR1 | |
| SCHEMBL861845 | 1.00 | MAOA (0.40) | MAOAMAOBPARP1NR1H3TAAR1 | |
| SCHEMBL2598856 | 1.00 | MAOA (0.40) | MAOAMAOBPARP1NR1H3TAAR1 | |
| SCHEMBL860846 | 0.83 | MEN1 (0.31) | S1PR1PIM1PIM2 | |
| SCHEMBL860847 | 0.83 | MEN1 (0.31) | S1PR1PIM1PIM2 | |
| SCHEMBL860696 | 0.83 | MAOA (0.46) | MAOAMAOBPARP1S1PR1S1PR5 | |
| SCHEMBL2598950 | 0.83 | MAOA (0.46) | MAOAMAOBPARP1S1PR1S1PR5 | |
| SCHEMBL860697 | 0.83 | MAOA (0.46) | MAOAMAOBPARP1S1PR1S1PR5 | |
| SCHEMBL861248 | 0.82 | CLK4 (0.44) | MAOAMAOBKDM4EHRH3PARP3 | |
| SCHEMBL861249 | 0.82 | CLK4 (0.44) | MAOAMAOBKDM4EHRH3PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |