Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 11/20 | 0.42 |
| ▸ | DRD3 | P35462 | 11/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860408 | 1.00 | DPP4 (0.45) | DPP4ACHEDRD2DRD3PARP1 | |
| SCHEMBL1805034 | 1.00 | DPP4 (0.45) | DPP4ACHEDRD2DRD3PARP1 | |
| SCHEMBL2598885 | 1.00 | DPP4 (0.45) | DPP4ACHEDRD2DRD3PARP1 | |
| SCHEMBL860407 | 1.00 | DPP4 (0.45) | DPP4ACHEDRD2DRD3PARP1 | |
| SCHEMBL1805032 | 1.00 | DPP4 (0.45) | DPP4ACHEDRD2DRD3PARP1 | |
| SCHEMBL2598895 | 0.88 | DRD2 (0.50) | DPP4DRD2DRD3PARP1 | |
| SCHEMBL2598894 | 0.88 | DRD2 (0.50) | DPP4DRD2DRD3PARP1 | |
| SCHEMBL19818358 | 0.88 | DRD2 (0.50) | DPP4DRD2DRD3PARP1 | |
| SCHEMBL1801902 | 0.88 | DRD2 (0.50) | DPP4DRD2DRD3PARP1 | |
| SCHEMBL1801900 | 0.88 | DRD2 (0.50) | DPP4DRD2DRD3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |