Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25986948 | 0.85 | NPC1 (0.31) | — | |
| SCHEMBL27120208 | 0.83 | MEN1 (0.31) | MEN1KMT2AMOGAT2 | |
| SCHEMBL25992561 | 0.82 | BACE1 (0.33) | OPRK1 | |
| SCHEMBL26022857 | 0.81 | KRAS (0.33) | — | |
| SCHEMBL25999425 | 0.80 | OPRK1 (0.30) | OPRK1 | |
| SCHEMBL25938420 | 0.80 | BTK (0.33) | — | |
| SCHEMBL27120419 | 0.80 | S1PR1 (0.31) | — | |
| SCHEMBL25996642 | 0.79 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL25989028 | 0.77 | — | — | |
| SCHEMBL25997931 | 0.72 | KRAS (0.36) | MEN1KMT2APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |