Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26022857 | 0.87 | KRAS (0.33) | CARM1 | |
| SCHEMBL25938420 | 0.86 | BTK (0.33) | CARM1 | |
| SCHEMBL25988966 | 0.85 | MEN1 (0.39) | — | |
| SCHEMBL27120419 | 0.85 | S1PR1 (0.31) | — | |
| SCHEMBL25986054 | 0.77 | — | — | |
| SCHEMBL25993969 | 0.77 | SLC6A2 (0.36) | — | |
| SCHEMBL27006159 | 0.76 | SDCBP (0.37) | NPC1RAB9AMAPTTHRB | |
| SCHEMBL25997931 | 0.75 | KRAS (0.36) | NPC1RAB9AMAPT | |
| SCHEMBL25993613 | 0.71 | TLR7 (0.32) | NPC1RAB9AATMTLR7CYP2D6 | |
| SCHEMBL26418968 | 0.71 | HRH3 (0.49) | NPC1RAB9AATMTLR7CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |