Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598179 | 0.90 | PARP3 (0.39) | PARP3DRD2DRD3PDE9APARP1 | |
| SCHEMBL2598178 | 0.90 | PARP3 (0.39) | PARP3DRD2DRD3PDE9APARP1 | |
| SCHEMBL860339 | 0.90 | PARP3 (0.39) | PARP3DRD2DRD3PDE9APARP1 | |
| SCHEMBL860340 | 0.90 | PARP3 (0.39) | PARP3DRD2DRD3PDE9APARP1 | |
| SCHEMBL2598140 | 0.83 | MEN1 (0.43) | DRD2DRD3KMT2APDE9ABCHE | |
| SCHEMBL2598139 | 0.83 | MEN1 (0.43) | DRD2DRD3KMT2APDE9ABCHE | |
| SCHEMBL860645 | 0.83 | MEN1 (0.43) | DRD2DRD3KMT2APDE9ABCHE | |
| SCHEMBL860646 | 0.83 | MEN1 (0.43) | DRD2DRD3KMT2APDE9ABCHE | |
| SCHEMBL2598895 | 0.82 | DRD2 (0.50) | PARP3DRD2DRD3S1PR1S1PR5 | |
| SCHEMBL2598894 | 0.82 | DRD2 (0.50) | PARP3DRD2DRD3S1PR1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | claimed |
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |