Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK2 | Q16620 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | MST1R | Q04912 | 1/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.33 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806277 | 1.00 | NTRK2 (0.33) | NTRK2JAK2NTRK1METFGFR1 | |
| SCHEMBL1806279 | 1.00 | NTRK2 (0.33) | NTRK2JAK2NTRK1METFGFR1 | |
| SCHEMBL2599050 | 1.00 | NTRK2 (0.33) | NTRK2JAK2NTRK1METFGFR1 | |
| SCHEMBL1803783 | 0.91 | RXRA (0.36) | NTRK2JAK2GRIA2PTPN5KCNH2 | |
| SCHEMBL1803782 | 0.91 | RXRA (0.36) | NTRK2JAK2GRIA2PTPN5KCNH2 | |
| SCHEMBL1803785 | 0.91 | RXRA (0.36) | NTRK2JAK2GRIA2PTPN5KCNH2 | |
| SCHEMBL860194 | 0.91 | HPGD (0.36) | L3MBTL1CDC7PIM1 | |
| SCHEMBL860195 | 0.91 | HPGD (0.36) | L3MBTL1CDC7PIM1 | |
| SCHEMBL860649 | 0.87 | CLK4 (0.38) | NTRK2JAK2NTRK1METFGFR1 | |
| SCHEMBL861248 | 0.87 | CLK4 (0.44) | NTRK2BRD4CLK4DYRK1BFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |