Sugi Predict

Sugi Predict / Compounds / SCHEMBL259910

SCHEMBL259910

SCHEMBL259910

Cc1cc(C)n2ccnc2c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.41
▸ CDK8 P49336 2/20 0.36
▸ ROCK1 Q13464 2/20 0.36
▸ FLT1 P17948 1/20 0.36
▸ CDK9 P50750 1/20 0.36
▸ LIMK1 P53667 1/20 0.36
▸ CLK4 Q9HAZ1 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.33
▸ LMNA P02545 1/20 0.33
▸ CCR1 P32246 1/20 0.33
▸ CCR5 P51681 1/20 0.33
▸ CCR8 P51685 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ GABRG2 P18507 1/20 0.33
▸ GABRB3 P28472 1/20 0.33
▸ GABRA3 P34903 1/20 0.33
▸ CYP11B1 P15538 2/20 0.32
▸ CYP11B2 P19099 2/20 0.32
▸ CHEK1 O14757 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2673260 0.79 L3MBTL1 (0.34) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL28873689 0.79 NPC1 (0.35) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL24448759 0.79 CDK8 (0.34) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL21849076 0.76 FLT1 (0.33) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL22043134 0.76 IKBKB (0.38) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL6762668 0.76 PDE10A (0.39) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL23055630 0.76 IKBKB (0.35) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL21849255 0.76 KDM4E (0.33) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL19525932 0.76 KEAP1 (0.36) KDM4ECDK8ROCK1FLT1CDK9
SCHEMBL21816236 0.75 EGLN2 (0.34) CDK8ROCK1FLT1CDK9LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9018217-B2 Phenylimidazole derivatives as PDE10A enzyme inhibitors H. LUNDBECK A/S (DK) 2015-04-28 — — US claimed
US-20150025081-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2015-01-22 — — US claimed
EP-2318394-B1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS LUNDBECK & CO AS H (DK) 2014-01-22 — — EP claimed
US-20120135987-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2012-05-31 — — US claimed
JP-2011524381-A — — 2011-09-01 — — JP claimed
WO-2011072695-A1 PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2011-06-23 — — WO claimed
EP-2318394-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. Lundbeck A/S (DK) 2011-05-11 — — EP claimed
US-20100016303-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2010-01-21 — — US claimed
WO-2009152825-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2009-12-23 — — WO claimed
EP-3660023-B1 THIENOPYRIMIDINEDIONE COMPOUNDS AS ACC INHIBITORS AND USE THEREOF NANJING SANHOME PHARMACEUTICAL CO LTD (CN) 2023-03-08 — — EP disclosed
EP-3660023-A1 COMPOUND AS ACC INHIBITOR AND USE THEREOF Nanjing Sanhome Pharmaceutical Co., Ltd. (CN) 2020-06-03 — — EP disclosed
WO-2020065614-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2020-04-02 — — WO disclosed
WO-2019020041-A1 COMPOUND AS ACC INHIBITOR AND USE THEREOF 南京圣和药业股份有限公司 2019-01-31 — — WO disclosed
US-9669029-B2 Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors H. LUNDBECK A/S (DK) 2017-06-06 — — US disclosed
WO-2012065612-A1 IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2012-05-24 — — WO disclosed
US-20120129836-A1 Imidazole derivatives as PDE10A enzyme inhibitors H. LUNDBECK A/S (DK) 2012-05-24 — — US disclosed
US-8133897-B2 Phenylimidazole derivatives as PDE10A enzyme inhibitors H. LUNDBECK A/S (DK) 2012-03-13 — — US disclosed
WO-2011072695-A1 PHENYLIMIDAZOLE DERIVATIVES COMPRISING AN ETHYNYLENE LINKER AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2011-06-23 — — WO disclosed
WO-2011072694-A1 HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2011-06-23 — — WO disclosed
US-20100016303-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2010-01-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120129836-A1 Imidazole derivatives as PDE10A enzyme inhibitors PDE5A, PDE3A, PDE3B KDM4E 535/4885CDK8 3046/4885ROCK1 308/4885
US-20100016303-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS PDE10A, PDE5A, PDE3B KDM4E 356/4885CDK8 1785/4885ROCK1 522/4885
US-20120135987-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS PDE10A, PDE5A, PDE3B KDM4E 356/4885CDK8 1785/4885ROCK1 522/4885
US-20150025081-A1 NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS PDE10A, PDE5A, PDE3B KDM4E 356/4885CDK8 1785/4885ROCK1 522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.