Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 14/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16448920 | 0.83 | PDE10A (0.48) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL259048 | 0.81 | PDE10A (0.46) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL15473325 | 0.76 | PIK3CG (0.46) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL6118117 | 0.76 | PDE10A (0.48) | PDE10APIK3CGRECQL | |
| SCHEMBL2036746 | 0.74 | PDE10A (0.49) | PDE10A | |
| SCHEMBL2254006 | 0.73 | NUDT1 (0.57) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL7842296 | 0.71 | PIK3CG (0.39) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL259219 | 0.70 | RECQL (0.73) | PDE10AKDM4EALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL15469651 | 0.70 | PIK3CG (0.41) | PDE10APIK3CGNPC1RAB9AKDM4E | |
| SCHEMBL13384210 | 0.69 | PDE10A (0.46) | PDE10ANPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669029-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2017-06-06 | — | — | US | disclosed |
| US-9669029-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2017-06-06 | — | — | US | disclosed |
| US-9669029-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2017-06-06 | — | — | US | disclosed |
| US-9592230-B2 | Substituted imidazoles as PDE10A inhibitors | H. LUNDBECK A/S (DK) | 2017-03-14 | — | — | US | disclosed |
| US-9592230-B2 | Substituted imidazoles as PDE10A inhibitors | H. LUNDBECK A/S (DK) | 2017-03-14 | — | — | US | disclosed |
| US-9592230-B2 | Substituted imidazoles as PDE10A inhibitors | H. LUNDBECK A/S (DK) | 2017-03-14 | — | — | US | disclosed |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-10-15 | — | — | US | disclosed |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-10-15 | — | — | US | disclosed |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-10-15 | — | — | US | disclosed |
| US-9096589-B2 | Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2015-08-04 | — | — | US | disclosed |
| US-8133897-B2 | Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-03-13 | — | — | US | disclosed |
| US-8133897-B2 | Phenylimidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-03-13 | — | — | US | disclosed |
| WO-2011072694-A1 | HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011072694-A1 | HETEROAROMATIC PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |
| EP-2318394-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. Lundbeck A/S (DK) | 2011-05-11 | — | — | EP | disclosed |
| US-20100016303-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2010-01-21 | — | — | US | disclosed |
| US-20100016303-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2010-01-21 | — | — | US | disclosed |
| US-20100016303-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2010-01-21 | — | — | US | disclosed |
| WO-2009152825-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009152825-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016303-A1 | NOVEL PHENYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | PDE10A, PDE5A, PDE3B | PDE10A 1/4885PIK3CG 1194/4885NPC1 1261/4885 |
| US-20150290191-A1 | Heteroaromatic Phenylimidazole derivatives as PDE10A enzyme inhibitors | PDE10A, PDE3B, PDE12 | PDE10A 1/4885PIK3CG 1293/4885NPC1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.