Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25995344 | 0.93 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL25993051 | 0.81 | PRMT5 (0.33) | PRMT5WDR77 | |
| SCHEMBL19116890 | 0.81 | HDAC8 (0.30) | — | |
| SCHEMBL25994276 | 0.80 | HRH3 (0.32) | — | |
| SCHEMBL27117866 | 0.80 | CHRM1 (0.38) | — | |
| SCHEMBL25997577 | 0.79 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL27118055 | 0.78 | METAP1 (0.35) | — | |
| SCHEMBL25982112 | 0.77 | — | — | |
| SCHEMBL27122864 | 0.76 | SIGMAR1 (0.32) | — | |
| SCHEMBL27117909 | 0.76 | SIGMAR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |