Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993687 | 0.80 | PRMT5 (0.32) | — | |
| SCHEMBL27118055 | 0.78 | METAP1 (0.35) | — | |
| SCHEMBL27117866 | 0.73 | CHRM1 (0.38) | — | |
| SCHEMBL19116890 | 0.73 | HDAC8 (0.30) | — | |
| SCHEMBL25995344 | 0.73 | PRMT5 (0.32) | — | |
| SCHEMBL21622132 | 0.73 | HRH3 (0.36) | HRH3PTGS1PTGS2ACACB | |
| SCHEMBL25986178 | 0.73 | THRB (0.39) | HRH3ACACB | |
| SCHEMBL27311402 | 0.72 | MAPK14 (0.34) | — | |
| SCHEMBL25937877 | 0.72 | CASP1 (0.31) | — | |
| SCHEMBL25937879 | 0.71 | PDK2 (0.34) | PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |